Synthesis of substituted N-benzyl pyridones via an O- to N-alkyl migration.

نویسندگان

  • Erica L Lanni
  • Michael A Bosscher
  • Bartel D Ooms
  • Christina A Shandro
  • Bruce A Ellsworth
  • Carolyn E Anderson
چکیده

A new LiI-promoted O- to N-alkyl migration has been developed for the conversion of O-alkylated 2-hydroxy pyridines, quinolines, and pyrimidines to the corresponding N-alkylated heterocycles in good to excellent yields (57-99%). This method serves as an efficient means for the preparation of N-benzyl pyridones, quinolones, and pyrimidones.

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عنوان ژورنال:
  • The Journal of organic chemistry

دوره 73 16  شماره 

صفحات  -

تاریخ انتشار 2008